News & Perspectives

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Projects Delivered

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Predicting Respiratory Exacerbations in Primary Care Holly Tibble Lung / Respiratory

Lung conditions like asthma and COPD can be incredibly unpredictable, and it can be very hard to foretell when an attack is likely to occur. Inconsistent use of an inhaler (or other treatment), smoking, obesity, history of respiratory infections, and more, are associated with higher risk of attacks. Despite knowing so many risk factors, identifying who is actually going to have an attack has proven a challenging task.
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Safety and real-world effectiveness of advanced treatments used in rheumatology and bone disease Athina Spiliopoulou Other

This research will examine conventional and newer medications used in rheumatology. This will include medicines for inflammatory diseases, like rheumatoid arthritis and lupus. These diseases occur when the body's immune system overreacts, causing swelling and pain. It will also include medicines used in diseases that affect the bones, like osteoporosis and rickets. We will study the benefits and side effects of medications over a longer time period compared to trials and consider groups often excluded from trials, such as those with more medical conditions. We will also examine differences in clinical factors and patient characteristics to see if these can help with treatment decisions. This is important because in many cases we cannot predict which medication will work for a patient before starting the treatment.
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Publications

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Large language models in oncology: promise, pitfalls, and the path to real-world adoption Sam McInerney et al Cancer

Oncology services across the UK and Europe are under significant pressure. Cancer diagnoses are projected to increase by 21% by 2040. With a system already at breaking point, the need for tools to support safe, evidence-based decision making has never been greater.
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Hospital ward transitions and outcomes in critical care survivors: A multi-hospital cohort study Toby Falodun et al Emergency Care

Background: Hospital ward transitions remain poorly understood despite their importance to patient flow and efficiency. Transition patterns are shaped by local policy and pathways, but in critically ill patients, transitions may also accumulate in response to clinical complexity. This study aimed to characterise patterns of ward transitions, identify determinants of ward transition frequency, and evaluate associations with adverse patient outcomes.
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