Publications

Objectives: This study sought to evaluate the effectiveness and safety of risk stratification with high-sensitivity cardiac troponin in patients with suspected acute coronary syndrome stratified as low and intermediate risk.

This project aimed to address a major bottleneck in conducting research on confidential data - the final stage of "Output Statistical Disclosure Control" (OSDC). This is where staff in a Trusted Research Environment (TRE) conduct manual checks to ensure that things a researcher wishes to take out - such as tables, plots, statistical and/or AI models- do not cause risk to any individual's privacy.

As part of a series on Machine Learning disclosure risk in Trusted Research Environments (TREs), this article is intended to introduce TRE managers to the conceptual problems and work being done to address them.

Synthetic Data has the potential to improve efficiency of data analysis for researchers. However, there is no standard approach to synthetic data governance, access controls or infrastructure requirements, and researchers may face inconsistencies in how they can access or use synthetic data across trusted research environments.

Background: We explored the feasibility of linking research datasets to electronic health records to identify acute stroke computed tomography (CT) brain features associated with post-stroke dementia.

Introduction: Overall dementia diagnosis rates are substantially below true rates. Hospital admissions of older people involve cognitive and functional assessments relevant to dementia diagnosis. These assessments could be harnessed to contribute to identifying patients for further assessment. Yet relationships of inpatient cognitive tests with known dementia are unclear.

As the prevalence of multimorbidity grows, provision of effective healthcare is more challenging. Both multimorbidity and complexity in healthcare delivery may be associated with worse outcomes. We studied consecutive, unique emergency non-surgical hospitalisations for patients over 50 years old to three hospitals in Scotland, UK between 2016 and 2024 using linked primary care and hospital records to define multimorbidity (2 + long-term conditions), and timestamped hospital electronic health record (EHR) contacts with nursing and rehabilitation providers to describe intensity of ...

International practice guidelines consider high-sensitivity cardiac troponin (hs-cTn) T and I equivalent irrespective of the clinical indication. This assumption has recently been challenged by clinical and experimental studies suggesting possible differences between cTnT and cTnI, including a diurnal rhythm for cTnT but not cTnI, and a stronger association of hs-cTnT with renal function.