News & Perspectives

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Projects Delivered

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Predicting Respiratory Exacerbations in Primary Care Holly Tibble Lung / Respiratory

Lung conditions like asthma and COPD can be incredibly unpredictable, and it can be very hard to foretell when an attack is likely to occur. Inconsistent use of an inhaler (or other treatment), smoking, obesity, history of respiratory infections, and more, are associated with higher risk of attacks. Despite knowing so many risk factors, identifying who is actually going to have an attack has proven a challenging task.
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Safety and real-world effectiveness of advanced treatments used in rheumatology and bone disease Athina Spiliopoulou Other

This research will examine conventional and newer medications used in rheumatology. This will include medicines for inflammatory diseases, like rheumatoid arthritis and lupus. These diseases occur when the body's immune system overreacts, causing swelling and pain. It will also include medicines used in diseases that affect the bones, like osteoporosis and rickets. We will study the benefits and side effects of medications over a longer time period compared to trials and consider groups often excluded from trials, such as those with more medical conditions. We will also examine differences in clinical factors and patient characteristics to see if these can help with treatment decisions. This is important because in many cases we cannot predict which medication will work for a patient before starting the treatment.
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Publications

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Prevalence and outcomes of recorded dementia vary by data source: a population cohort study of 133,407 older adults Rose S Penfold et al Mental Health

Dementia diagnoses are captured across multiple routine data sources, but discrepancies between these may affect both care and research. This study determined the prevalence and overlap of recorded dementia across primary care, hospital and community prescribing data in a UK regional cohort, and examined whether outcomes differed by the setting in which dementia was first recorded.
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Cardiac Troponin Thresholds in Children and Young Adults: A Multi-Center Cohort Study Alexander J F Thurston et al Heart / Cardiology

Background: The role of high-sensitivity cardiac troponin (cTn) assays for children and young adults is uncertain, and no guidance is available on diagnostic thresholds. This study evaluates the effect of applying pediatric compared to adult upper reference limits (URLs) for cTn.
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