Theme: Liver Disease
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Project reference: DL_2023_004

Project Lead: James Dear, Eleanor Dixon

Some medicines can cause the side effect of liver injury which is the commonest cause of liver failure (organ damage).  Medicines causing liver injury are also a common cause of emergency hospital admissions and liver transplants; they are the main reasons medicines are removed from the market.  Antibiotics are the main group of medicines which cause liver injury independent of the medicine dosage.  

In this project, we are investigating whether data routinely collected by the NHS can be used to monitor liver injury caused by two antibiotics. Both amoxicillin and co-amoxiclav (antibiotics) are commonly prescribed for chest problems but the latter antibiotic causes liver injury far more frequently than the former. This means we can compare the blood test results (identifying liver injury) for these two drugs. This is beneficial because data already being collected (blood test results) can be used to measure the safety of certain drugs.